B7-H4 overexpression contributes to poor prognosis and drug-resistance in triple-negative breast cancer.

Ling WangChao YangXin-Bo LiuLi WangFu-Biao Kang

Published in: Cancer cell international (2018)

Our data show that B7-H4 is a biomarker indicative of a poor prognosis in TNBC patients and at least partially downregulated in chemoresistance via PTEN/PI3K/AKT pathway. Targeting B7-H4 might provide an attractive therapeutic approach specifically for TNBC patients.

Keyphrases

poor prognosis
end stage renal disease
long non coding rna
ejection fraction
chronic kidney disease
newly diagnosed
prognostic factors
peritoneal dialysis
cell proliferation
drug delivery
patient reported outcomes
transcription factor
big data
cancer stem cells