Inhibition of Secretin/Secretin Receptor Axis Ameliorates NAFLD Phenotypes.

Lixian ChenNan WuLindsey KennedyHeather FrancisLudovica CeciTianhao ZhouNiharika SamalaKonstantina KyritsiChaodong WuAmelia SybengaBurcin EkserWasim DarConstance Lynn AtkinsVik MeadowsShannon GlaserGianfranco Alpini

Published in: Hepatology (Baltimore, Md.) (2021)

The biliary SCT/SCTR/miR-125b axis promotes liver steatosis by up-regulating lipid biosynthesis gene Elovl1. Targeting the biliary SCT/SCTR/miR-125b axis may be key for ameliorating phenotypes of human NAFLD/NASH.

Keyphrases

endothelial cells
insulin resistance
copy number
gene expression
type diabetes
cancer therapy
adipose tissue
fatty acid