Comorbid alcohol use disorder and post-traumatic stress disorder: A proof-of-concept randomized placebo-controlled trial with buprenorphine and naltrexone combination treatment.

Lori L DavisIsmene L PetrakisPatricia D PilkintonTracy NolenNathan VandergriftShawn HirschSeth D NorrholmThomas R Kosten

Published in: Alcohol (Hanover, York County, Pa.) (2023)

This is the first study to evaluate the potential of κ-opioid receptor antagonism for the treatment of comorbid AUD and PTSD. The combination of buprenorphine and naltrexone-XR showed no significant improvement over placebo for the composite, PTSD or alcohol measures.

Keyphrases

alcohol use disorder
double blind
social support
placebo controlled
phase iii
clinical trial
posttraumatic stress disorder
binding protein