Serum from pregnant women with gestational diabetes mellitus increases the expression of FABP4 mRNA in primary subcutaneous human pre-adipocytes.

Lan LiSe Jin LeeSong Yi KookTae Gyu AhnJi Yeon LeeJong Yun Hwang

Published in: Obstetrics & gynecology science (2017)

Our results suggest that FABP4 is higher in placenta and decidua from pregnant women with GDM. Increased circulating FABP4 in maternal serum from pregnant women with GDM may originate from adipocytes and the placenta. Circulating FABP4 can induce increased insulin resistance and decreased insulin sensitivity.

Keyphrases

binding protein
pregnant women
adipose tissue
pregnancy outcomes
insulin resistance
endothelial cells
high fat diet induced
poor prognosis
type diabetes
metabolic syndrome
polycystic ovary syndrome
body mass index
induced pluripotent stem cells
long non coding rna