Natural alkaloid bouchardatine ameliorates metabolic disorders in high-fat diet-fed mice by stimulating the sirtuin 1/liver kinase B-1/AMPK axis.

Yong RaoHong YuLin GaoYu-Ting LuZhao XuHong LiuLian-Quan GuJi-Ming YeShuo-Bin Chen

Published in: British journal of pharmacology (2017)

Bou may have therapeutic potential for obesity-related metabolic diseases by increasing the capacity of energy expenditure in adipose tissues and liver through a mechanism involving the SIRT1-LKB1-AMPK axis.

Keyphrases

high fat diet
insulin resistance
high fat diet induced
skeletal muscle
adipose tissue
protein kinase
metabolic syndrome
type diabetes
gene expression
weight loss
oxidative stress
ischemia reperfusion injury
tyrosine kinase
body mass index