Sciatic nerve stimulation alleviates neuropathic pain and associated neuroinflammation in the dorsal root ganglia in a rodent model.
Chia-En WongWentai LiuChi-Chen HuangPo-Hsuan LeeHan-Wei HuangYu ChangHsin-Tien LoHui-Fang ChenLi-Chieh KuoJung-Shun LeePublished in: Journal of translational medicine (2024)
NRL induced hyperactivation of SGCs, which had increased expression of NP-related ion channels. Reciprocal activation of SGCs and M1 macrophages surrounding the primary sensory neurons was mediated by the HIF-1α and NF-κB pathways. SNS suppressed SGC hyperactivation and skewed M1 macrophage towards M2. Our findings establish SGC activation as a crucial pathomechanism in the gliopathic alterations in NP, which can be modulated by SNS neuromodulation.
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