Longitudinal Development of Peripapillary Hyper-Reflective Ovoid Masslike Structures Suggests a Novel Pathological Pathway in Multiple Sclerosis.

Axel PetzoldDanko CoricLisanne J BalkSteffen HamannBernard M J UitdehaagAlastair K DennistonPearse A KeaneDavid Paul Crabb

Published in: Annals of neurology (2020)

These data suggest that PHOMS are a novel finding in MS pathology. Future research is needed to determine whether development of PHOMS in MS is due to intermittently raised intracranial pressure or an otherwise impaired "glymphatic" outflow from eye to brain. ANN NEUROL 2020;88:309-319.

Keyphrases

multiple sclerosis
white matter
mass spectrometry
ms ms
optical coherence tomography
high resolution
optic nerve
electronic health record
resting state
current status
cross sectional
deep learning
data analysis
neural network
cerebral ischemia