Integrating deep mutational scanning and low-throughput mutagenesis data to predict the impact of amino acid variants.

Yunfan Fu Justin Bedő Anthony T Papenfuss Alan F Rubin

Published in: GigaScience (2023)

We show that improved model performance depends on the compatibility of the DMS and AS assays, and the scale of improvement is closely related to the correlation between DMS and AS results.

Keyphrases

amino acid
crispr cas
electronic health record
copy number
high throughput
high resolution
big data
electron microscopy
gene expression
mass spectrometry
machine learning
artificial intelligence
data analysis
genome wide