Distinct Biological Types of Ocular Adnexal Sebaceous Carcinoma: HPV-Driven and Virus-Negative Tumors Arise through Nonoverlapping Molecular-Genetic Alterations.

Michael T TetzlaffJonathan L CurryJing NingOded SagivThomas L KandlBo PengDiana BellMark J RoutbortCourtney W HudgensDoina IvanTae-Boom KimKen ChenAgda Karina EterovicKenna ShawVictor G PrietoAnna YemelyanovaBita Esmaeli

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2018)

Together, our findings establish a potential molecular-genetic framework by which to understand the development and progression of OA sebaceous carcinoma and provide key molecular-genetic insights to direct the design of novel therapeutic interventions.

Keyphrases

genome wide
copy number
single molecule
physical activity
high grade
dna methylation
optical coherence tomography