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GBA1 inactivation in oligodendrocytes affects myelination and induces neurodegenerative hallmarks and lipid dyshomeostasis in mice.

Ilaria GregorioLoris RussoEnrica TorrettaPietro BarbaciniGabriella ContariniGiada PacinelliDario BizzottoManuela MoriggiPaola BraghettaFrancesco PapaleoCecilia GelfiEnrico MoroMatilde Cescon
Published in: Molecular neurodegeneration (2024)
Our study sheds light on the contribution of oligodendrocytes in GBA1-related diseases and supports the need for better characterizing oligodendrocytes as actors playing a role in neurodegenerative diseases, also pointing at them as potential novel targets to set a brake to disease progression.
Keyphrases
  • type diabetes
  • high fat diet induced
  • adipose tissue
  • fatty acid
  • skeletal muscle
  • human health
  • insulin resistance