Analysis of Immune-Cell Distribution of Bone Marrow in Patients with Myelodysplastic Syndrome.
Chun-Liang LinChing-Chan LinTzu-Ting ChenWen-Jyi LoShu-Ling TzengPublished in: Hematology reports (2023)
Myelodysplastic syndrome (MDS) immunity plays an important role in the proliferation and apoptosis of aberrant cells. Immune dysregulation has been studied in various prognostic subgroups. This study analyzed 60 patients with MDS via multidimensional flow cytometry to evaluate the expression of aberrant markers, such as CD7 and cytoplasmic CD3 on lymphocytes. The Revised International Prognostic Scoring System (IPSS-R) scores were used to classify the patients into risk groups. The results showed a significant downregulation of CyCD3- T cells in low-intermediate versus high-risk patients ( p = 0.013). This study is the first to show that a significant decrease in cyCD3- T cells in patients with a lower IPSS-R score may indicate microenvironmental changes conducive to transformation in MDS.
Keyphrases
- end stage renal disease
- bone marrow
- ejection fraction
- chronic kidney disease
- newly diagnosed
- flow cytometry
- prognostic factors
- oxidative stress
- cell cycle arrest
- induced apoptosis
- poor prognosis
- cell death
- mesenchymal stem cells
- cell proliferation
- endoplasmic reticulum stress
- peripheral blood
- patient reported outcomes
- binding protein
- solid state