Sitagliptin improved glucose assimilation in detriment of fatty-acid utilization in experimental type-II diabetes: role of GLP-1 isoforms in Glut4 receptor trafficking.

E RamírezB PicatosteA González-BrisM OteoF CruzA Caro-VadilloJ EgidoJ TuñónM A MorcilloÓscar Lorenzo

Published in: Cardiovascular diabetology (2018)

Besides of its anti-hyperglycemic effect, sitagliptin-enhanced GLP-1 may ameliorate diastolic dysfunction in type-II diabetes by shifting fatty acid to glucose utilization in the cardiomyocyte, and thus, improving cardiac efficiency and reducing lipolysis.

Keyphrases

fatty acid
type diabetes
glycemic control
left ventricular
cardiovascular disease
blood glucose
adipose tissue
blood pressure
oxidative stress
heart failure