Angiogenic role of miR-20a in breast cancer.
Gines Luengo-GilEnrique Gonzalez-BillalabeitiaSergio Alejo Perez-HenarejosEsther Navarro ManzanoAsuncion Chaves-BenitoElena Garcia-MartinezElisa Garcia-GarreVicente VicenteFrancisco AyalaPublished in: PloS one (2018)
Transfection of breast cancer cells with miR-20a induces vascular changes in endothelial tube-formation assays. Expression of miR-20a in breast invasive carcinomas is associated with a distinctive angiogenic pattern consisting in large vessels, anomalous glomeruloid microvascular proliferations and high VEGFA expression. Our results suggest a role for miR-20a in the regulation of breast cancer angiogenesis, and raise the possibility of its use as an angiogenic biomarker.