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Angiogenic role of miR-20a in breast cancer.

Gines Luengo-GilEnrique Gonzalez-BillalabeitiaSergio Alejo Perez-HenarejosEsther Navarro ManzanoAsuncion Chaves-BenitoElena Garcia-MartinezElisa Garcia-GarreVicente VicenteFrancisco Ayala
Published in: PloS one (2018)
Transfection of breast cancer cells with miR-20a induces vascular changes in endothelial tube-formation assays. Expression of miR-20a in breast invasive carcinomas is associated with a distinctive angiogenic pattern consisting in large vessels, anomalous glomeruloid microvascular proliferations and high VEGFA expression. Our results suggest a role for miR-20a in the regulation of breast cancer angiogenesis, and raise the possibility of its use as an angiogenic biomarker.
Keyphrases
  • long non coding rna
  • cell proliferation
  • poor prognosis
  • long noncoding rna
  • breast cancer cells
  • endothelial cells
  • vascular endothelial growth factor
  • binding protein
  • high throughput
  • high grade
  • young adults