Long non-coding RNA MALAT1 modulate cell migration, proliferation and apoptosis by sponging microRNA-146a to regulate CXCR4 expression in acute myeloid leukemia.

Xian-Fu Sheng Li-Li Hong Hui Li Fei-Yan Huang Qiang Wen Hai-Feng Zhuang

Published in: Hematology (Amsterdam, Netherlands) (2021)

Our results showed that MALAT1 regulates migration, proliferation and apoptosis by sponging miR-146a to regulate CXCR4 expression in AML cells, providing novel insights into the role of MALAT1 as a therapeutic target in AML.

Keyphrases

long non coding rna
poor prognosis
cell migration
cell cycle arrest
induced apoptosis
cell death
endoplasmic reticulum stress
acute myeloid leukemia
signaling pathway
oxidative stress
pi k akt
cell proliferation
allogeneic hematopoietic stem cell transplantation
binding protein