Enhanced tryptophan-kynurenine metabolism via indoleamine 2,3-dioxygenase 1 induction in dermatomyositis.
Yanting ShihMengya ChenShile ChenSzeman CheungYongheng ChenQian ZhaoKe XueFeng XueXiaosong ChenMin ZhouHao LiJie ZhengYunchen LeHua CaoPublished in: Clinical rheumatology (2022)
DM patients with enhanced Trp-Kyn metabolism at disease onset are characterized by more severe disease status and poor prognosis. Intrinsic immune regulation function via enhanced Trp-Kyn metabolism by IDO1 induction may be a potential therapeutic target in DM. Key Points • HPLC-MS identified increased serum Kyn/Trp ratio in DM patients, which positively correlated with levels of muscle enzymes and inflammatory markers and was downregulated upon treatment. • Cox regression analyses identified ln(Kyn/Trp) as an independent prognostic predictor of mortality in DM. • Monitoring intrinsic immune regulation function should be considered a potential therapeutic target in DM patients.
Keyphrases
- poor prognosis
- end stage renal disease
- chronic kidney disease
- newly diagnosed
- ejection fraction
- ms ms
- mass spectrometry
- peritoneal dialysis
- long non coding rna
- multiple sclerosis
- skeletal muscle
- rheumatoid arthritis
- coronary artery disease
- patient reported outcomes
- cardiovascular disease
- adipose tissue
- risk assessment
- risk factors
- climate change
- human health
- disease activity
- interstitial lung disease
- smoking cessation
- patient reported
- drug induced
- solid phase extraction