Distinct regulations driving YAP1 expression loss in poroma, porocarcinoma and RB1-deficient skin carcinoma.

Kervarrec ThibaultEric FrouinChristine CollinAnne TalletMatthias TallegasDaniel PissalouxFranck TirodeSerge GuyétantMahtab SamimiPauline GaboriaudAntoine TouzéDavid SchramaRoland HoubenFlore Tabareau-DelalandeAnne NeuhartArnaud de la FouchardièreAmélie OsioBénédicte Cavelier-BalloySara Laurent-RousselPierre SohierTilmant CyprienBrigitte BalmeFanny BelzungMarie-Laure JullieBernard CribierMaxime BattistellaNicolas Macagno

Published in: Histopathology (2023)

In addition to gene fusion, we report that transcriptional repression of YAP1 can be observed in skin tumours with RB1 inactivation, including MCC and a subset of SCC.

Keyphrases

soft tissue
wound healing
poor prognosis
gene expression
copy number
genome wide
oxidative stress
dna methylation
genome wide identification
heat shock