Adverse roles of mast cell chymase-1 in chronic obstructive pulmonary disease.
Gang LiuAndrew G JarnickiKeshav Raj PaudelWenying LuRidhima WadhwaAshleigh M PhilpHannelore Van EeckhoutteJacqueline E MarshallVamshikrishna MalylaAngelica KatsifisMichael FrickerNicole G HansbroKamal DuaNazanin Z KermaniMathew Suji EapenAngelica I TiotiuK Fan ChungGaetano CaramoriKen BrackeIssssswan M AdcockSukhwinder S SohalPeter A B WarkBrian G OliverPhilip M HansbroPublished in: The European respiratory journal (2022)
CMA1/mMCP5 promotes the pathogenesis of COPD, in part, by inducing TNF-α expression and release from lung macrophages. Inhibiting hCMA1 may be a novel treatment for COPD.