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Treatment Updates for Neuromuscular Channelopathies.

Nantaporn JitpimolmardEmma MatthewsDoreen Fialho
Published in: Current treatment options in neurology (2020)
The treatment of skeletal muscle channelopathies combines dietary and lifestyle advice together with pharmacological interventions. The rarity of these conditions remains a barrier for clinical studies but the example of the aggregated n-of-1 trial of mexiletine shows that innovative trial design can overcome these hurdles. Further research is required to test efficacy of drugs shown to have promising characteristics in preclinical experiments such as safinamide, riluzule and magnesium for myotonia or bumetanide for hypokalaemic periodic paralysis.
Keyphrases
  • skeletal muscle
  • study protocol
  • clinical trial
  • physical activity
  • phase iii
  • randomized controlled trial
  • adipose tissue
  • mesenchymal stem cells
  • combination therapy
  • drug induced