Sex-dependent differences in vulnerability to early risk factors for posttraumatic stress disorder: results from the AURORA study.
Stephanie HaeringAntonia V SeligowskiSarah D LinnstaedtVasiliki MichopoulosStacey L HouseFrancesca L BeaudoinXinming AnThomas C NeylanGari D CliffordLaura T GermineScott L RauchJohn P HaranAlan B StorrowChristopher LewandowskiPaul I MuseyPhyllis L HendrySophia SheikhChristopher W JonesBrittany E PunchesRobert A SworNina T GentileLauren A HudakJose L PascualMark J SeamonClaire PearsonDavid A PeakRoland C MerchantRobert M DomeierNiels K RathlevBrian J O'NeilLeon D SanchezSteven E BruceSteven E HarteSamuel A McLeanRonald C KesslerKarestan C KoenenJennifer S StevensAbigail D PowersPublished in: Psychological medicine (2024)
Our findings indicate mechanisms to which men might be particularly vulnerable, demonstrating that known PTSD risk factors might behave differently in women and men. Analyses did not identify any risk factors to which women were more vulnerable than men, pointing toward further mechanisms to explain women's higher PTSD risk. Our study illustrates the need for a more systematic examination of sex differences in contributors to PTSD severity after trauma, which may inform refined preventive interventions.