Detection of SARS-CoV-2 infection in thyroid follicular cells from a COVID-19 autopsy series.

Sofia MacedoAna PestanaLiliana SantosCelestino NevesSusana GuimarãesAmaro Duarte-NetoMarisa DolhnikoffPaulo SaldivaGeorgina AlvesRute OliveiraDidier CabanesFátima CarneiroManuel Sobrinho-SimõesPaula Soares

Published in: European thyroid journal (2022)

Our results obtained in thyroid specimens from deceased COVID-19 patients indicate that thyrocytes can be directly infected by SARS-CoV-2 since we detected the presence of SARS-CoV-2 genome in follicular cells. Nevertheless, we did not find a clear correlation between the presence of viral genome and the expression of the host factors for virus entry, namely ACE-2, TMPRSS2, and furin.

Keyphrases

sars cov
respiratory syndrome coronavirus
induced apoptosis
poor prognosis
cell cycle arrest
genome wide
angiotensin ii
coronavirus disease
angiotensin converting enzyme
endoplasmic reticulum stress
kidney transplantation
oxidative stress
label free
cell death
binding protein
sensitive detection
quantum dots