Dextromethorphan-Bupropion for the Treatment of Depression: A Systematic Review of Efficacy and Safety in Clinical Trials.

Dania AkbarTaeho Greg Rhee Felicia Ceban Roger Chun-Man Ho Kayla M Teopiz Bing CaoMehala SubramaniapillaiAngela T H Kwan Joshua Daniel Rosenblat Roger S McIntyre

Published in: CNS drugs (2023)

Current evidence suggests that the combination of dextromethorphan and bupropion is a well-tolerated, rapid-acting treatment option for adults with MDD. Initial success with AXS-05 supports the mechanistic role of glutamatergeric and sigma 1 signaling in the pathophysiology of MDD.

Keyphrases

clinical trial
depressive symptoms
randomized controlled trial
sleep quality
quantum dots
open label
phase ii