Optimization of Albuminuria-Lowering Treatment in Diabetes by Crossover Rotation to Four Different Drug Classes: A Randomized Crossover Trial.

Viktor Rotbain CurovicNiels JongsMarjolein Y A M KroonenEmilie H ZobelTine W HansenTaha SenGozewijn D LavermanAdriaan KooyFrederik PerssonPeter RossingHiddo J Lambers Heerspink

Published in: Diabetes care (2023)

We demonstrated a large and reproducible variation in participants' responses to different UACR-lowering drug classes. These data support systematic rotation through different drug classes to overcome therapy resistance to RAS inhibition.

Keyphrases

type diabetes
open label
cardiovascular disease
adverse drug
study protocol
drug induced
stem cells
emergency department
phase iii
randomized controlled trial
electronic health record
placebo controlled
glycemic control
data analysis