A new cytotoxic cardenolide from the roots of Calotropis gigantea.

Mai T T NguyenKhang D H NguyenPhu Hoang Dang Hai Xuan Nguyen Suresh AwaleNhan T Nguyen

Published in: Natural product research (2020)

Bioactivity-guided isolation of the CHCl3-soluble fraction of the roots of Calotropis gigantea was carried out to obtain a new cardenolide glycoside, caloside G. Its absolute structure was elucidated based on NMR and ECD spectroscopic data interpretation. Caloside G showed noteworthy cytotoxicity against the PANC-1 human pancreatic and HeLa human cervical carcinoma cell lines, with the submicromolar IC50 values of 0.038 and 0.09 µM, respectively.

Keyphrases

endothelial cells
magnetic resonance
pluripotent stem cells
high resolution
electronic health record
machine learning
cell death
big data
mass spectrometry