Prevention of acquired sensorineural hearing loss in mice by in vivo Htra2 gene editing.

Xi GuDaqi WangZhijiao XuJinghan WangLuo GuoRenjie ChaiGenglin LiYi-Lai ShuHuawei Li

Published in: Genome biology (2021)

These findings demonstrate the safe and effective prevention of aminoglycoside-induced deafness via Htra2 gene editing and support further development of the CRISPR/Cas9 technology in the treatment of non-inherited hearing loss as well as other non-inherited diseases.

Keyphrases

crispr cas
hearing loss
genome editing
high glucose
diabetic rats
type diabetes
drug induced
cystic fibrosis
drug resistant
adipose tissue
wild type