Deep Red Light Driven Hydrogen Evolution by Heterojunction Polymer Dots for Diabetic Wound Healing.
Feixue MiZhao LiuXinyu WangYingjie WangJunfeng YangZhe WangShengyan YinXiaofeng FangPeng ShuXuanjun ZhangChangfeng WuPublished in: Angewandte Chemie (International ed. in English) (2024)
We describe small heterojunction polymer dots (Pdots) with deep-red light catalyzed H 2 generation for diabetic skin wound healing. The Pdots with donor/acceptor heterojunctions showed remarkably enhanced photocatalytic activity as compared to the donor or acceptor nanoparticles alone. We encapsulate the Pdots and ascorbic acid into liposomes to form Lipo-Pdots nanoreactors, which selectively scavenge ⋅OH radicals in live cells and tissues under 650 nm light illumination. The antioxidant capacity of the heterojunction Pdots is ~10 times higher than that of the single-component Pdots described previously. Under a total light dose of 360 J/cm 2 , the Lipo-Pdots nanoreactors effectively scavenged ⋅OH radicals and suppressed the expression of pro-inflammatory cytokines in skin tissues, thereby accelerating the healing of skin wounds in diabetic mice. This study provides a feasible solution for safe and effective treatment of diabetic foot ulcers.
Keyphrases
- wound healing
- solar cells
- visible light
- gene expression
- induced apoptosis
- poor prognosis
- drug delivery
- fluorescent probe
- cell cycle arrest
- photodynamic therapy
- oxidative stress
- high resolution
- cell death
- long non coding rna
- soft tissue
- signaling pathway
- endoplasmic reticulum stress
- reduced graphene oxide
- anti inflammatory
- drug release
- binding protein
- smoking cessation
- tandem mass spectrometry
- simultaneous determination
- walled carbon nanotubes