Selective pharmacological inhibition of DDR1 prevents experimentally-induced glomerulonephritis in prevention and therapeutic regime.

Solange MollYukari YasuiAhmed AbedTakeshi MurataHideaki ShimadaAkira MaedaNaoshi FukushimaMasakazu KanamoriSabine UhlesLaura BadiThomas CagarelliIvan FormentiniFaye DrawnelGuy GeorgesTobias BergauerRodolfo GasserR Daniel BonfilRafael FridmanHans RichterJuergen FunkMarcus J MoellerChristos ChatziantoniouMarco Prunotto

Published in: Journal of translational medicine (2018)

Together, these results suggest that DDR1 inhibition might be an attractive and promising pharmacological intervention for the treatment of GN, predominantly by targeting the renal epithelium.

Keyphrases

randomized controlled trial
high glucose
diabetic rats
drug induced
mouse model
oxidative stress