MMP-14 and CD44 in Epithelial-to-Mesenchymal Transition (EMT) in ovarian cancer.

Maria Caroline VosEva HollemansNicole EzendamHarry FeijenDorry BollBrenda PijlmanHans van der PuttenPaul KlinkhamerToin H van KuppeveltAnneke A M van der WurffLeon F A G Massuger

Published in: Journal of ovarian research (2016)

The subgroup of patients with double expression of MMP-14 and CD44 had a poor prognosis despite complete debulking. Serous subtype in advanced-stage patients and CD44 expression were found to be correlated with vimentin expression, and CD44 expression was found to be significantly correlated with complete debulking. However, a significant correlation between EMT and clinical parameters was not found.

Keyphrases

poor prognosis
long non coding rna
end stage renal disease
epithelial mesenchymal transition
nk cells
chronic kidney disease
binding protein
ejection fraction
newly diagnosed
high grade
prognostic factors
lymph node
patient reported
double blind