Anti-Inflammatory and Anti-Bacterial Potential of Mulberry Leaf Extract on Oral Microorganisms.
Dokyeong KimKyung-Hee KangPublished in: International journal of environmental research and public health (2022)
Mulberry leaves extract ( Morus alba extracts; MAE) is known to have therapeutic potentials for numerous human diseases, including diabetes, neurological disorders, cardiovascular diseases, and cancers. However, there has not been sufficient research proving therapeutic effects on oral disease and its related oral risk factors. Thus, we investigated whether MAE has any anti-inflammatory and anti-bacterial effects on risk factors causing oral infectious diseases. To examine the anti-inflammatory response and bacterial inhibition of MAE, we measured intracellular reactive oxygen species (ROS) generation, production of pro-inflammatory cytokines, and the bacterial growth rate. Our study showed that MAE has anti-inflammatory activities, which inhibit the ROS generation and suppressed the production of pro-inflammatory cytokines (TNF-α and IL-6) in human monocyte THP-1 cells by stimulating lipopolysaccharide (LPS) and/or F. nucleatum , which are the virulent factors in periodontal diseases. Furthermore, MAE inhibited the bacterial growth on oral microorganisms ( F. nucleatum and S. mutans ) infected THP-1 cells. These findings suggested that MAE could be a potential natural source for therapeutic drugs in oral infectious disease.
Keyphrases
- anti inflammatory
- infectious diseases
- inflammatory response
- reactive oxygen species
- risk factors
- endothelial cells
- cardiovascular disease
- induced apoptosis
- type diabetes
- oxidative stress
- cell cycle arrest
- cell death
- dna damage
- dendritic cells
- cell proliferation
- climate change
- coronary artery disease
- young adults
- induced pluripotent stem cells
- pluripotent stem cells
- high resolution
- blood brain barrier
- weight loss