Conserved genomic neighborhood is a strong but no perfect indicator for a direct interaction of microbial gene products.

Published in: BMC bioinformatics (2020)

Our phylogenetically comprehensive analysis confirmed that complex formation is a strong evolutionary factor that conserves genome neighborhoods. On the other hand, for 55% of the cases analyzed here, classification failed. Either, the interaction partner was not present in a ± 10 gene window or was not the most frequent gene product.

Keyphrases

genome wide
copy number
genome wide identification
dna methylation
microbial community
physical activity
gene expression