Intramuscular transplantation of bone marrow cells prolongs the lifespan of SOD1G93A mice and modulates expression of prognosis biomarkers of the disease.

Amaya RandoDiego PastorMari Carmen Viso-LeónAnna MartínezRaquel ManzanoXavier NavarroRosario OstaSalvador Martínez

Published in: Stem cell research & therapy (2018)

This work demonstrates that stem cell transplantation in the muscle prolonged the lifespan, increased motoneuron survival and slowed disease progression, which was also assessed by genetic expression analysis.

Keyphrases

stem cell transplantation
bone marrow
high dose
induced apoptosis
poor prognosis
cell cycle arrest
mesenchymal stem cells
genome wide
low dose
amyotrophic lateral sclerosis
binding protein
cell therapy
gene expression
free survival
insulin resistance
transcription factor
metabolic syndrome