Comparative analysis of the clinical characteristics and outcomes of patients with Wilms tumor in the United Kingdom and Japan.
Kayo NakataRichard WilliamsYoshiaki KinoshitaTsugumichi KoshinagaVeronica MorozReem Al-SaadiGordan M VujanicTakaharu OueKathy Pritchard-JonesPublished in: Pediatric blood & cancer (2021)
Differences in age of onset, tumor size at diagnosis, and histology may reflect differences in the genetic background of patients with WT between countries, but population-based phenotype-genotype data are lacking. The difference in survival probability for stage IV patients may be due to different diagnostic criteria or different treatment strategies. Prospective, international clinical studies including genomic analyses are needed to confirm these findings and improve clinical practice.
Keyphrases
- end stage renal disease
- clinical practice
- ejection fraction
- newly diagnosed
- chronic kidney disease
- prognostic factors
- peritoneal dialysis
- gene expression
- genome wide
- type diabetes
- electronic health record
- adipose tissue
- deep learning
- machine learning
- metabolic syndrome
- big data
- insulin resistance
- dna methylation
- cross sectional