Synthesis of macrocyclic thiolactone peptides via photochemical intramolecular radical acyl thiol-ene ligation.
Alby BennyEoin M ScanlanPublished in: Chemical communications (Cambridge, England) (2024)
A photochemical acyl thiol-ene reaction can be used to rapidly cyclise fully unprotected peptides bearing both a thioacid and alkene to form peptide thiolactones. This strategy represents the first reported synthesis of peptide thiolactones under radical-mediated conditions.