Original research: Second IVIg course in Guillain-Barré syndrome with poor prognosis: the non-randomised ISID study.
Christine VerboonBianca van den BergDavid R CornblathEsmee VenemaKenneth C GorsonMichael P LunnHester LingsmaPeter Van den BerghThomas HarboKathleen BatemanYann PereonSøren H SindrupSusumu KusunokiJames MillerZhahirul IslamHans-Peter HartungGovindsinh ChavadaBart C JacobsRichard A C HughesPieter A van Doornnull nullPublished in: Journal of neurology, neurosurgery, and psychiatry (2019)
This observational study did not show better outcomes after a second IVIg course in GBS with poor prognosis. The study was limited by small numbers and baseline imbalances. Lack of improvement was likely an incentive to start a second IVIg course. A prospective randomised trial is needed to evaluate whether a second IVIg course improves outcome in GBS.