ICH3, a selective alpha7 nicotinic acetylcholine receptor agonist, modulates adipocyte inflammation associated with obesity.

G ScabiaR CancelloC DallanoceS BergerC MateraA DattiloA ZulianI BaroneG CeccariniF SantiniM De AmiciA M Di BlasioMargherita Maffei

Published in: Journal of endocrinological investigation (2020)

We proved that ICH3 is an anti-inflammatory drug, able to reduce inflammatory cytokines in human adipocytes and to blunt the effects of obesity on WAT inflammatory profile, on glucose tolerance and on tissue insulin sensitivity.

Keyphrases

insulin resistance
high fat diet induced
adipose tissue
metabolic syndrome
weight loss
anti inflammatory
oxidative stress
type diabetes
endothelial cells
weight gain
skeletal muscle
pluripotent stem cells