Continuous Positive Airway Pressure plus Mandibular Advancement Therapy (PAPMAT): study protocol for an adaptive randomised crossover trial comparing the benefits and costs of combining two established treatments for obstructive sleep apnoea.

Martin LawSofia VillarNicholas OscroftVictoria StonemanJulia Fox-RushbyYi-Da ChiuJo SteeleThomas DevineClaire FrancisThomas ClaydonGraham HillKa Keat LimJoanna RaynerMandy WilliamsEmma SpiresTimothy Quinnell

Published in: Trials (2023)

PAPMAT was registered with ISRCTN prior to recruitment beginning (ISRCTN Registry 2021): https://www.isrctn.com/ISRCTN33966032 . Registered on 17th November 2021.

Keyphrases

positive airway pressure
obstructive sleep apnea
sleep apnea
clinical trial
open label
study protocol
double blind
phase iii
placebo controlled
phase ii
physical activity
stem cells
randomized controlled trial
sleep quality
depressive symptoms
bone marrow