Impaired Renal HCO3 - Excretion in Cystic Fibrosis.

Peder BergSamuel L SvendsenMads Vaarby SorensenCasper K LarsenJesper Frank AndersenSøren Jensen-FangelMajbritt JeppesenRainer SchreiberInes CabritaKarl KunzelmannJens Leipziger

Published in: Journal of the American Society of Nephrology : JASN (2020)

These results define the mechanism of secretin-induced urinary HCO3 - excretion, explain metabolic alkalosis in patients with CF, and suggest feasibility of an in vivo human CF urine test to validate drug efficacy.

Keyphrases

cystic fibrosis
pseudomonas aeruginosa
endothelial cells
high glucose
lung function
drug induced
diabetic rats
induced pluripotent stem cells
pluripotent stem cells
chronic obstructive pulmonary disease
electronic health record