MicroRNA-139-5p Regulates Fibrotic Potentials via Modulation of Collagen Type 1 and Phosphorylated p38 MAPK in Uterine Leiomyoma.

So Hyun Ahn Hee Yon Kim Inha Lee Jae Hoon Lee Si Hyun Cho Young Sik Choi

Published in: Yonsei medical journal (2021)

Expression of miR-139-5p is downregulated in leiomyoma cells and modulation of miR-139-5p may be involved inthe pathogenesis of leiomyomas through the regulation of collagen type 1 and phosphorylated p38 MAPK. Therefore, miR-139-5p is a potential therapeutic target for leiomyoma.

Keyphrases

induced apoptosis
poor prognosis
cell cycle arrest
wound healing
tissue engineering
idiopathic pulmonary fibrosis
endoplasmic reticulum stress
oxidative stress
binding protein
long non coding rna
cell proliferation
climate change