Phase 2a, randomized, double-blind, placebo-controlled, multicentre, parallel-group study of an H4 R-antagonist (JNJ-39758979) in adults with uncontrolled asthma.
Alexa P KollmeierA GreenspanX L XuP E SilkoffE S BarnathanM J LozaJ JiangB ZhouB ChenR L ThurmondPublished in: Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology (2018)
The findings suggest potential benefit of H4 R antagonists on lung function and asthma control in eosinophilic asthma patients and warrant further evaluation of this mechanism in asthma with eosinophilic inflammation. NCT00946569.
Keyphrases
- lung function
- chronic obstructive pulmonary disease
- cystic fibrosis
- double blind
- air pollution
- placebo controlled
- end stage renal disease
- clinical trial
- study protocol
- newly diagnosed
- chronic kidney disease
- oxidative stress
- squamous cell carcinoma
- prognostic factors
- phase ii
- phase iii
- randomized controlled trial
- peritoneal dialysis