Ferroptosis inhibitor alleviates Radiation-induced lung fibrosis (RILF) via down-regulation of TGF-β1.

Xuan LiLijie DuanSujuan YuanXibing ZhuangTiankui QiaoJian He

Published in: Journal of inflammation (London, England) (2019)

Our data suggested that ferroptosis played a critical role in RILF, ferroptosis inhibitor liproxstatin-1 alleviated RILF via down-regulation of TGF-β1 by the activation of Nrf2 pathway. The effectiveness of ferroptosis inhibition on RILF provides a novel therapeutic target for RILF.

Keyphrases

cell death
radiation induced
transforming growth factor
radiation therapy
randomized controlled trial
oxidative stress
systematic review
electronic health record
big data
machine learning
data analysis