Clinical and Genomic Characterization of Bladder Carcinomas With Glandular Phenotype.
Nima AlmassiKarissa A WhitingAntoun ToubajiAndrew T LenisEmmet J JordanHelen WonAshley M RegazziYing-Bei ChenAnuradha GopalanSahussapont Joseph SirintrapunSamson W FineSatish K TickooIrina OstrovnayaEugene J PietzakEugene K ChaAlvin C GohTimothy F DonahueHarry W HerrS Machele DonatGuido DalbagniBernard H BochnerMin Yuen TeoSamuel A FuntJonathan E RosenbergVictor E ReuterDean F BajorinDavid B SolitHikmat A Al-AhmadieGopakumar V IyerPublished in: JCO precision oncology (2022)
The genomic profile of bladder adenocarcinomas resembled colorectal adenocarcinomas, whereas UC with glandular differentiation more closely resembled UC, NOS. Differences in outcomes among patients with glandular bladder cancer variants undergoing surgical resection were largely driven by differences in stage. Cisplatin-based NAC demonstrated activity in UC with glandular differentiation, suggesting NAC should be considered for this histologic variant.