Impaired Mineral Ion Metabolism in a Mouse Model of Targeted Calcium-Sensing Receptor (CaSR) Deletion from Vascular Smooth Muscle Cells.
Martin SchepelmannMarianna RanieriIrene Lopez-FernandezThomas S WebberleySarah C BrennanPolina L YarovaJoao GracaUmar-Khetaab HanifChristian MüllerTeresa ManhardtMartina SalzmannHelen QuasnichkaSally A PriceDonald T WardThierry GilbertVladimir V MatchkovRobert A FentonAmanda HerbergerJenna HwongChristian Santa MariaChia-Ling TuEnikő KállayGiovanna ValentiWenhan ChangDaniela RiccardiPublished in: Journal of the American Society of Nephrology : JASN (2022)
These results suggest that, in addition to CaSR's established role in the parathyroid-kidney-bone axis, expression of CaSR in vascular smooth muscle cells directly contributes to total body mineral ion homeostasis.