Shortened Leukocyte Telomere Length Associates with an Increased Prevalence of Chronic Health Conditions among Survivors of Childhood Cancer: A Report from the St. Jude Lifetime Cohort.
Aesun ShinZhenghong LiNa QinCarrie R HowellCarmen L WilsonJohn EastonHeather L MulderMichael N EdmonsonMichael C RuschJinghui ZhangMelissa M HudsonYutaka YasuiLeslie L RobisonKirsten K NessZhaoming WangPublished in: Clinical cancer research : an official journal of the American Association for Cancer Research (2020)
LTL is significantly shorter among childhood cancer survivors than noncancer controls, and is associated with CHCs and health behaviors, suggesting LTL as an aging biomarker may be a potential mechanistic target for future intervention studies designed to prevent or delay onset of CHCs in childhood cancer survivors.See related commentary by Walsh, p. 2281.