Protective Role of Short-Chain Fatty Acids against Ang- II-Induced Mitochondrial Dysfunction in Brain Endothelial Cells: A Potential Role of Heme Oxygenase 2.
Modar KassanYoungin KwonUndral MunkhsaikhanAmal M SahyounTauheed IshratMaría GalánAlexis A GonzalezAmmaar H AbidiAdam KassanKarima Ait-AissaPublished in: Antioxidants (Basel, Switzerland) (2023)
SCFAs treatment restored endothelial cells and mitochondrial function following Ang-II-induced oxidative stress. SCFAs exert these beneficial effects by acting on HO-2. Our results are opening the door for more studies to investigate the effect the of SCFAs/HO-2 axis on hypertension and obesity-induced cerebrovascular diseases.
Keyphrases
- high glucose
- endothelial cells
- diabetic rats
- fatty acid
- angiotensin ii
- blood pressure
- type diabetes
- metabolic syndrome
- insulin resistance
- drug induced
- weight loss
- hydrogen peroxide
- white matter
- oxidative stress
- body mass index
- nitric oxide
- resting state
- adipose tissue
- blood brain barrier
- functional connectivity
- brain injury
- case control