Chronic alcohol intake regulates expression of SARS-CoV2 infection-relevant genes in an organ-specific manner.
Marion M FriskeFrancesco GiannoneMona SengerRobin SeitzAnita C HanssonRainer SpanagelPublished in: Alcoholism, clinical and experimental research (2023)
We conclude that alcohol-induced upregulation of Ace2 gene expression can lead to an elevated stochastic probability of virus entry into cells and may thus confer a molecular risk for SARS-CoV2 infection.
Keyphrases
- gene expression
- poor prognosis
- induced apoptosis
- respiratory syndrome coronavirus
- alcohol consumption
- cell cycle arrest
- high glucose
- dna methylation
- drug induced
- signaling pathway
- diabetic rats
- cell proliferation
- long non coding rna
- angiotensin ii
- angiotensin converting enzyme
- cell death
- sars cov
- weight gain
- endothelial cells
- bioinformatics analysis
- physical activity
- body mass index
- single molecule
- weight loss
- genome wide analysis
- stress induced