Comorbidities in mild autonomous cortisol secretion and the effect of treatment: Systematic review and meta-analysis.

The present systematic review and meta-analysis highlights the relevance of MACS, since both cardiometabolic morbidities and mortality appeared increased in patients with MACS compared to patients with non-functioning incidentalomas. However, due to heterogeneous definitions, various outcomes, selective reporting, and missing data, the reported pooled estimates need to be interpreted with caution. The small number of patients in randomized trials prevents any strong conclusion on the causality between MACS and these comorbidities.