Ankylosing spondylitis is associated with aberrant DNA methylation of IFN regulatory factor 8 gene promoter region.
Mengya ChenMeng WuXingxing HuJiajia YangRenfang HanYubo MaXu ZhangYaping YuanRui LiuGuangming JiangShengqian XuJianhua XuZongwen ShuaiFa-Ming PanPublished in: Clinical rheumatology (2019)
We found a significant hypermethylation of the IRF8 gene promoter and a downregulation of the mRNA levels of the IRF8 gene in AS patients. This suggests that aberrant methylation of the IRF8 gene promoter may probably contribute to the development and pathogenesis of AS through regulating the expression of mRNA.
Keyphrases
- dna methylation
- genome wide
- copy number
- ankylosing spondylitis
- gene expression
- transcription factor
- dendritic cells
- genome wide identification
- end stage renal disease
- rheumatoid arthritis
- binding protein
- chronic kidney disease
- ejection fraction
- newly diagnosed
- poor prognosis
- immune response
- signaling pathway
- disease activity
- prognostic factors
- peritoneal dialysis
- patient reported outcomes
- genome wide analysis