The efficacy and safety of oral antibiotic treatment in patients with chronic low back pain and Modic changes: A systematic review and meta-analysis.
Arnold Yu Lok WongG Michael MallowSabina M PintoAlexander L HornungSamuel S RudisillKhaled AboushaalaPeter M UdbyHoward S AnDino SamartzisPublished in: JOR spine (2023)
Although oral antibiotics were statistically superior to placebo in reducing LBP-related disability in patients with CLBP and concomitant MC1, its clinical significance remains uncertain. Future large-scale high-quality RCTs are warranted to validate the effectiveness of antibiotics in individuals with CLBP.