Reversal of lactate and PD-1-mediated macrophage immunosuppression controls growth of PTEN/p53-deficient prostate cancer.

Kiranj Chaudagar Hanna M Hieromnimon Rimpi Khurana Brian Labadie Taghreed Hirz Shenglin Mei Raisa Hasan Jordan S Shafran Anne Kelley Eva Apostolov Ghamdan Al-Eryani Kate Harvey Srikrishnan Rameshbabu Mayme Loyd Kaela M Bynoe Catherine Drovetsky Solanki Aniruddhsingh Erica Markiewicz Marta Zamora Xiaobing Fan Stephan C Schürer Alexander Swarbrick David Brian Sykes Akash Patnaik

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2023)

Immunometabolic strategies that reverse lactate and PD-1-mediated TAM immunosuppression, in combination with ADT, warrant further investigation in PTEN-deficient mCRPC patients.

Keyphrases

prostate cancer
end stage renal disease
cell proliferation
ejection fraction
newly diagnosed
chronic kidney disease
pi k akt
prognostic factors
peritoneal dialysis
radical prostatectomy
patient reported outcomes