Cardiovascular risk factor assessment in late-onset seizures: A study protocol to assess the value of structured intervention.
David LarssonSignild ÅsbergJohan SundströmPetrea FridJohan ZelanoPublished in: Epilepsia open (2024)
A first seizure in a middle-aged or older person indicates a higher risk of stroke. It is not known whether investigating and treating blood pressure, blood cholesterol, or similar risk factors after a first seizure is an effective way to prevent stroke. A traditional clinical study would need too many patients and it would be unethical not to treat the control group. We have designed a study in which participating neurology departments change their practice to test and treat vascular risk factors. Patients are then compared to historic controls using registered data.
Keyphrases
- risk factors
- late onset
- end stage renal disease
- blood pressure
- ejection fraction
- randomized controlled trial
- middle aged
- newly diagnosed
- chronic kidney disease
- study protocol
- healthcare
- clinical trial
- primary care
- peritoneal dialysis
- type diabetes
- metabolic syndrome
- big data
- adipose tissue
- brain injury
- artificial intelligence
- insulin resistance
- skeletal muscle
- double blind
- cerebral ischemia
- data analysis