The Impact of Type II Diabetes on Tongue Dysplasia and p16-Related Aging Process: An Experimental Study.

Eren AltunHasmet YaziciErhan ArslanKamil Gokce TulaciHaydar Ali Erken

Published in: Analytical cellular pathology (Amsterdam) (2019)

In our study, streptozotocin-induced experimental diabetes mellitus induced p16 expression but did not show any difference in p53, Bcl-2, and Ki67 levels. It should be considered in the studies that the pathological changes at the early stages of the relationship between DM and oral cancer may be related to p16 expression; however, it may also be linked with p16-related aging process.

Keyphrases

diabetic rats
poor prognosis
high glucose
type diabetes
cardiovascular disease
glycemic control
oxidative stress
squamous cell carcinoma
high fat diet
binding protein
endothelial cells
lymph node
long non coding rna
adipose tissue